Treatment for Metastatic Lung Cancer in Dogs

The Minimally Invasive Metastasectomy in Canines (MIMIC)

Currently Enrolling

The Minimally Invasive Metastasectomy in Canines (MIMIC) clinical trial is open for enrollment. Ethos Discovery is investigating a promising, minimally-invasive surgical treatment for lung metastasis caused by canine osteosarcoma. Participation in this study is subsidized, including any necessary procedures.

ELIGIBILITY CRITERIA:

• Dogs weighing >5 kgs with a diagnosis of osteosarcoma
• Local tumor controlled or able to be controlled through surgery or radiation
• Suspected or confirmed lung metastasis

The Objective of This Study: Following removal of the primary tumor and chemotherapy, the development of lung metastasis is the most common cause of mortality in dogs with osteosarcoma. The use of surgery to manage osteosarcoma metastases in dogs has been shown to be promising, but is not commonly used due to the risks of conventional thoracic surgery. We seek to reduce these risks and improve outcomes using minimally invasive surgical techniques.

The Study Process: Innovations in minimally invasive surgery have created a new opportunity to include surgical removal of lung metastases in dogs. Through these innovations, open chest surgery can be replaced by thoracoscopy, a surgical technique using miniature incisions in the chest wall to allow removal of lung nodules with the assistance of a magnified video camera. This has the potential to minimize the pain, morbidity, and recovery time to patients at a fraction of what’s observed with conventional techniques. We predict patients will be recovered within 2 days and able to begin returning to normal life.

Our Goal: The goal of our study is to assess the feasibility and tolerability of thoracoscopy for lung metastasis and eventually deliver this care as an outpatient procedure. These trials will also assess the therapeutic benefit to our canine patients and pave the way to conduct accelerated studies to identify new drugs to prevent lung metastases in both human and canine osteosarcoma.

If your dog has been diagnosed with lung metastasis caused by osteosarcoma, you may be eligible toparticipate in this trial. If you are interested, please fill out the form below. Our expert team of veterinarianswill be in touch to confirm eligibility and discuss next steps.