Scientific Programs
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Lung Tumor Fluid Dynamics Study
OpenCurrent chemotherapy treatments involve a direct injection into the tumor. We would like to use surgically removed lung tissue to better understand how drugs behave when they are injected into lung tumors in dogs, as well as humans, with lung tumors.
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Methylnaltrexone (MNTX) Clinical Study
OpenPostoperative regurgitation is a common side effect of general anesthesia; it is of clinical concern due to the increased risk of pneumonia. This study seeks to define the rate at which intravenously administered MNTX in healthy dogs is metabolized. Once defined, a future study will evaluate the efficacy of this treatment in reducing postoperative regurgitation in dogs.
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Necrotizing Meningoencephalitis Study for Pugs (SEEP/STEEP)
OpenNecrotizing Meningoencephalitis in Pugs (PDE) is a devastating disease. Clinical signs include seizures, circling, cognitive changes, and visual deficits. Our goal is to identify neurological abnormalities in Pugs with high genomic risk for PDE before the onset of the above-mentioned advanced clinical signs.
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Probiotic Study in Dogs
OpenEthos Discovery is studying a novel live probiotic product typically found in the gut of healthy dogs. This study seeks to evaluate the ability of specific probiotics to resolve diarrhea in dogs. If your dog is eligible to participate, all costs for exams and diagnostic tests will be fully covered.
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Evaluating the Tolerability of a Novel PCNA Inhibitor in Dogs with Cancer
ClosedProliferating cell nuclear antigen (PCNA) is an important protein necessary for the repair of DNA in cells. Cancer cells express a unique type of PCNA (termed caPCNA) which is only found at small quantities in non-cancer cells.
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Evaluating the Tolerability of Combination of Verdinexor and Doxorubicin in Dogs with Cancer
ClosedVerdinexor is a chemotherapy drug that has been conditionally approved by the FDA for the treatment of canine lymphoma. Verdinexor is a selective inhibitor of nuclear export (SINE) compound, and this family of drug has demonstrated encouraging results in preclinical studies when combined with other chemotherapeutic drugs.
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Pneumonia Pathogen Analysis
OpenPneumonia (infection in the lungs) is a common diagnosis in dogs and cats and can be caused by a variety of pathogens (i.e., bacteria, viruses, fungal organisms). Collecting fluid samples from the lungs of patients with pneumonia allows for tests to be performed that can identify the organism causing the infection.
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Metabolomics Trial to Evaluate for Systemic Consequences of Intestinal Dysbiosis
ClosedThe intestinal microbiota are highly functional, with a combined genome (termed the microbiome) that is approximately 130-160 times larger than the human or canine genome. The microbiome is a highly functional organ and produces approximately 1,000 different metabolites, many of which have systemic effects in the dog. Intestinal dysbiosis is defined as an alteration in
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ORBITS Clinical Study
OpenDespite years of active research in the field, high mortality rates associated with sepsis have remained unchanged over the last three decades; we aim to change this!
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Minimally Invasive Metastasectomy in Canines (MIMIC)
OpenFollowing removal of the primary tumor and adjuvant chemotherapy, the development of lung metastasis is the most common cause of mortality in dogs with osteosarcoma. A distinctive feature of lung metastases of osteosarcoma in human patients is the surprising benefit that can result from surgical resection of the lung nodules. The use of surgery to
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Tolerability of Oral Paclitaxel in Cancer-Bearing Dogs
ClosedPaclitaxel is a human chemotherapeutic that has demonstrated a broad spectrum of activity against several human and canine cancers. Previous formulations of paclitaxel have been poorly absorbed in dogs, limiting its therapeutic value. Oraxol is a novel oral formulation of paclitaxel that is combined with a second drug, Encequidar, which improves this issue of poor
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Cell-Based Therapy for Necrotizing Meningoencephalitis in Pugs
ClosedWe propose that the spontaneous, but strongly genetic-based model of canine Necrotizing meningoencephalitis (NME) presents a unique way to help demonstrate the feasibility of inflammatory neurological disease prevention therapy.
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