• Postoperative Pain Control Drug in Dogs – Methylnaltrexone Study

    Open

    Postoperative regurgitation is a common side effect of general anesthesia; it is of clinical concern due to the increased risk of pneumonia. This study seeks to define the rate at which intravenously administered MNTX in healthy dogs is metabolized. Once defined, a future study will evaluate the efficacy of this treatment in reducing postoperative regurgitation in dogs.

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  • Necrotizing Meningoencephalitis Study for Pugs (SEEP/STEEP)

    Open

    Necrotizing Meningoencephalitis in Pugs (PDE) is a devastating disease. Clinical signs include seizures, circling, cognitive changes, and visual deficits. Our goal is to identify neurological abnormalities in Pugs with high genomic risk for PDE before the onset of the above-mentioned advanced clinical signs.

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  • Arkus MB Probiotic Study in Dogs

    Open

    Arkus MB is a novel live probiotic product which consists of 3 bacterial species that are typically found in the gut of healthy dogs: Clostridium hiranonis, Megamonas funiformis, and Enterococcus faecium

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  • Evaluating the Tolerability of a Novel PCNA Inhibitor in Dogs with Cancer

    Open

    Proliferating cell nuclear antigen (PCNA) is an important protein necessary for the repair of DNA in cells. Cancer cells express a unique type of PCNA (termed caPCNA) which is only found at small quantities in non-cancer cells.

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  • Evaluating the Tolerability of Combination of Verdinexor and Doxorubicin in Dogs with Cancer

    Closed

    Verdinexor is a chemotherapy drug that has been conditionally approved by the FDA for the treatment of canine lymphoma. Verdinexor is a selective inhibitor of nuclear export (SINE) compound, and this family of drug has demonstrated encouraging results in preclinical studies when combined with other chemotherapeutic drugs.

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  • Pneumonia Pathogen Analysis

    Open

    Pneumonia (infection in the lungs) is a common diagnosis in dogs and cats and can be caused by a variety of pathogens (i.e., bacteria, viruses, fungal organisms). Collecting fluid samples from the lungs of patients with pneumonia allows for tests to be performed that can identify the organism causing the infection.

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  • Metabolomics Trial to Evaluate for Systemic Consequences of Intestinal Dysbiosis

    Open

    The intestinal microbiota are highly functional, with a combined genome (termed the microbiome) that is approximately 130-160 times larger than the human or canine genome. The microbiome is a highly functional organ and produces approximately 1,000 different metabolites, many of which have systemic effects in the dog. Intestinal dysbiosis is defined as an alteration in

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  • Omics Research-Based Identification of Targets in Sepsis (ORBITS)

    Open

    Sepsis is caused by a severe infection that enters the bloodstream and is associated with a high mortality rate. This high mortality rate has remained unchanged over the last three decades even though there has been active research in the area.

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  • Minimally Invasive Metastasectomy in Canines (MIMIC)

    Open

    Following removal of the primary tumor and adjuvant chemotherapy, the development of lung metastasis is the most common cause of mortality in dogs with osteosarcoma. A distinctive feature of lung metastases of osteosarcoma in human patients is the surprising benefit that can result from surgical resection of the lung nodules. The use of surgery to

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  • Tolerability of Oral Paclitaxel in Cancer-Bearing Dogs

    Closed

    Paclitaxel is a human chemotherapeutic that has demonstrated a broad spectrum of activity against  several human and canine cancers. Previous formulations of paclitaxel have been poorly absorbed in dogs, limiting its therapeutic value. Oraxol is a novel oral formulation of paclitaxel that is combined with a second drug, Encequidar, which improves this issue of poor

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  • Cell-Based Therapy for Necrotizing Meningoencephalitis in Pugs

    Closed

    We propose that the spontaneous, but strongly genetic-based model of canine Necrotizing meningoencephalitis (NME) presents a unique way to help demonstrate the feasibility of inflammatory neurological disease prevention therapy.

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  • Sepsis Risk in Dogs with Chemotherapy-Induced Neutropenia

    Closed

    Neutropenia (low white blood cell count) is a common side effect of chemotherapy in patients with cancer, with sepsis being a potential consequence. The timely identification and treatment of sepsis is paramount to the success of therapy.

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