Our Studies/ Scientific Programs

Hemangiosarcoma (HSA) is an aggressive cancer in dogs and carries a poor prognosis. There are limited therapeutic options for the treatment of HSA, with none currently providing a significant opportunity for long-term survival.

Following removal of the primary tumor and adjuvant chemotherapy, the development of lung metastasis is the most common cause of mortality in dogs with osteosarcoma. A distinctive feature of lung metastases of osteosarcoma in human patients is the surprising benefit that can result from surgical resection of the lung nodules. The use of surgery to

This study seeks to understand the intestinal absorption potential of a novel formulation of rapamycin when administered to dogs with naturally occurring cancer. The data from this study will be used to define an ideal dose of the drug to use in future cancer clinical studies.

Pneumonia (infection in the lungs) is a common diagnosis in dogs and cats and can be caused by a variety of pathogens (i.e., bacteria, viruses, fungal organisms). Collecting fluid samples from the lungs of patients with pneumonia allows for tests to be performed that can identify the organism causing the infection.

Necrotizing Meningoencephalitis in Pugs (PDE) is a devastating disease. Clinical signs include seizures, circling, cognitive changes, and visual deficits. Our goal is to identify neurological abnormalities in Pugs with high genomic risk for PDE before the onset of the above-mentioned advanced clinical signs.

This study aims to determine whether or not canine patients diagnosed with canine osteosarcoma (OSA) have intestinal dysbiosis and whether treating intestinal disease improves patient outcomes.

Postoperative regurgitation is a common side effect of general anesthesia; it is of clinical concern due to the increased risk of pneumonia. This study seeks to define the rate at which intravenously administered MNTX in healthy dogs is metabolized. Once defined, a future study will evaluate the efficacy of this treatment in reducing postoperative regurgitation in dogs.

Investigating predictive biomarkers in response to treatment of kidney disease Goal: Investigate whether biomarker RNA profiles can predict response to AR blockers for proteinuria in dogs with PLN. Inclusion Criteria: Dogs with chronic proteinuria (UPC >0.5) for which pre- and post-renal causes have been excluded (UPC >0.5 confirmed on at least two separate occurrences >2

Understanding personalized treatment options for Lymphoma cancer in dogs Canine Lymphoma Clinical Trial Study Goals: The Stratification of Outcomes for Lymphoma In Dogs (SOLID) study is a clinical trial focused on better understanding the genetics behind canine lymphoma. By studying changes in the DNA of these cancers, researchers hope to identify patterns that could lead to more

FICUSS Study Study Goals: FICUSS Study looks to improve understanding of Feline Idiopathic Cystitis. The collected samples will be used to help better understand the underlying pathophysiology of this disease, which can then be used to aid in the development of novel diagnostic tests and targeted therapies for this condition. Eligibility criteria: Male cats greater

Current chemotherapy treatments involve a direct injection into the tumor. We would like to use surgically removed lung tissue to better understand how drugs behave when they are injected into lung tumors in dogs, as well as humans, with lung tumors.