Our Studies/ Scientific Programs

Summary of Study: The MYC gene plays a role in many types of cancer. However, this gene and its effects were once thought to be impossible to target with therapy. Recent advances have changed this paradigm and made this a viable target for therapy. The purpose of this study is to determine if a novel

Summary of Study: The trial aims to evaluate the tolerability and adverse event profile of hemostatic gel in the setting of canine epistaxis of any cause. With this, we also are studying the potential hemostatic activity of hemostatic gel in canine epistaxis. Canine epistaxis was found to be a result from a variety of causes, including trauma, foreign bodies, infections, coagulopathies,

Summary of Study: The Stratification of Outcomes for Lymphoma In Dogs with Relapsed Lymphoma (SOLID-Relapse) study is a clinical trial focused on the follow- up of dogs previously enrolled in Ethos-SOLID. This population of relapsed patients will add the perspective of longitudinal analysis and provide a unique opportunity to study the role of functional precision medicine in treatment of relapsed lymphoma. 

Study on vessel sealing devices in elective spay/neuter operations for exotic pets Summary of Study: Spay and neuter procedures are surgeries recommended for and performed on most exotics companion mammals for population control, to prevent reproductive diseases including cancer, and to help reduce behavioral concerns. Evaluation of surgical techniques is of great importance to these

Advancing bone cancer research in dogs through Osteosarcoma Summary of Study Osteosarcoma is the most prevalent form of bone cancer in dogs, sharing many biological similarities with the disease in humans. Unfortunately, even when a tumor is completely removed through surgery, over 90% of dogs eventually die because the cancer spreads to their lungs. The

TIDBITS: Bio-markers for Immune-Mediated Thrombocytopenia and response to immunosuppression in dogs Goal: Investigate whether exosome RNA profiles in ITP differ in treatment of naive dogs compared to those that respond with immunosuppression Inclusion Criteria: Canine patients with platelet count < 40K Clinical evidence of bleeding Weight ≥ 2kg Ability to administer vincristine No other causes

Investigating predictive biomarkers in response to treatment of kidney disease Goal: Investigate whether biomarker RNA profiles can predict response to AR blockers for proteinuria in dogs with PLN. Inclusion Criteria: Dogs with chronic proteinuria (UPC >0.5) for which pre- and post-renal causes have been excluded (UPC >0.5 confirmed on at least two separate occurrences >2

Understanding personalized treatment options for Lymphoma cancer in dogs Canine Lymphoma Clinical Trial Study Goals: The Stratification of Outcomes for Lymphoma In Dogs (SOLID) study is a clinical trial focused on better understanding the genetics behind canine lymphoma. By studying changes in the DNA of these cancers, researchers hope to identify patterns that could lead to more

FICUSS Study Study Goals: FICUSS Study looks to improve understanding of Feline Idiopathic Cystitis. The collected samples will be used to help better understand the underlying pathophysiology of this disease, which can then be used to aid in the development of novel diagnostic tests and targeted therapies for this condition. Eligibility criteria: Male cats greater

Clinical Study: Diet and probiotic therapy for chronic enteropathy in dogs Currently Enrolling Comparison of diet and probiotic vs. diet alone to control clinical signs of chronic enteropathy and diarrhea in dogs Study Goals: This study aims to evaluate a new probiotic-based therapeutic for chronic enteropathy and chronic diarrhea in dogs. Targeted alteration of the

Minimally-invasive surgical bone cancer treatment for dogs CURRENTLY ENROLLING The MIMIC clinical trial is open for enrollment. Ethos Discovery is investigating a new minimally-invasive surgical treatment for canine osteosarcoma that has metastasized, or spread, to the lungs. This study is subsidized and all procedures will be provided at an affordable, low cost. Eligibility Criteria: •

We are collecting blood samples from eligible French Bulldogs to research biomarkers associated with hemorrhages (bleeding) in French bulldogs.